Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formedin situas nucleophiles
نویسندگان
چکیده
منابع مشابه
Palladium-catalyzed asymmetric allylic substitution reactions using new chiral phosphinooxathiane ligands.
The development of the new chiral ligands for use in asymmetric catalytic reactions has drawn considerable interest in the last 10 years. In this area, palladiumcatalyzed allylic substitution reactions have been shown to be effective tools for the construction of carbon-carbon and carbon-heteroatom bond1 formation, and several efficient enantioselective catalysts such as C2and C1symmetric biden...
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Compared to their C1-symmetric counterparts, planar chiral C2-symmetric metallocenyl P,N-ligands are efficient chiral ligands for Pd-catalyzed asymmetric allylic aminations, providing a number of amination products with high enantioselectivities. A non-C2-symmetric ferrocenyl P,N-ligand (a by-product obtained during the synthesis of the above C2-symmetric species) was also found to be an effici...
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The transition metal-catalyzed allylic substitution of unactivated allylic substrates (allylic alcohols, allylic ethers and allylic amines) is rapidly becoming an important area of research. There are several advantages to using these substrates in allylic substitution reactions: the use of unactivated alcohols minimizes the production of waste by-products and reaction steps; and allylic ethers...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2019
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c8sc04626c